کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6802983 | 1433519 | 2018 | 54 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Cerebellar gray matter explains bimanual coordination performance in children and older adults
ترجمه فارسی عنوان
ماده خاکستری سلول بنیادی کارکرد هماهنگی دو جانبه در کودکان و سالخوردگان را توضیح می دهد
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کلمات کلیدی
توسعه نوجوانان، سالخورده، مغز، مدل داخلی، تصویربرداری رزونانس مغناطیسی، جنبش،
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
سالمندی
چکیده انگلیسی
The cerebellum appears to undergo late maturation in children and early decline at older age. Whether these age-related changes affect bimanual coordination performance remains unclear at best. Here, we identified the ages at which bimanual coordination performance stops improving and starts declining. In an independent cohort, we defined brain regions of interest involved in bimanual coordination using functional magnetic resonance imaging. We used these regions of interest to investigate the extent to which the gray matter of cerebellar and other brain regions explains bimanual coordination performance from 10- to 80-year-olds. Results showed that bimanual coordination performance starts declining from the age of 40Â years. In participants aged 10-20Â years, cerebellar lobule VI was the only significant brain predictor of bimanual coordination performance. In participants aged 60-80Â years, this cerebellar region, together with the primary sensorimotor cortex, formed a group of strongest predictors. These results from 2 independent samples (10-20 and 60-80Â years) suggest that cerebellar lobule VI is critical for the development and preservation of bimanual coordination skills in children and older adults, respectively. In addition, post hoc analyses suggested that the primary motor cortex mediated the adverse effect of age on bimanual coordination performance in older adults.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neurobiology of Aging - Volume 65, May 2018, Pages 109-120
Journal: Neurobiology of Aging - Volume 65, May 2018, Pages 109-120
نویسندگان
Matthieu P. Boisgontier, Boris Cheval, Peter van Ruitenbeek, Koen Cuypers, Inge Leunissen, Stefan Sunaert, Raf Meesen, Hamed Zivari Adab, Olivier Renaud, Stephan P. Swinnen,