کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6802989 | 1433520 | 2018 | 28 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
The effect of white matter hyperintensities on cognition is mediated by cortical atrophy
ترجمه فارسی عنوان
تأثیر غلظت های ماده سفید بر شناختن توسط آتروفی کورتنی متاثر می شود
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کلمات کلیدی
کمبود شدید ماده سفید، ضخامت قشر، شناخت، بیماری آلزایمر، حافظه،
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
سالمندی
چکیده انگلیسی
White matter hyperintensities (WMH) have been linked to cognitive dysfunction and dementia, although the reasons are unclear. One possibility is that WMH promote neurodegeneration, which, in turn, affects cognition. We examined whether cortical thickness, a marker of neurodegeneration, mediates the relationship between WMH and cognition among 519 older adults. Using conditional process analysis modeling techniques, we examined the association between WMH volume and global cognition and tested whether cortical thickness mediates this relationship statistically. We also tested specific regional hypotheses to determine whether cortical thickness or volume in the medial temporal lobe mediates the relationship between WMH volume and memory. Increased total WMH volume was associated with poorer global cognition and memory. Global cortical thickness and medial temporal lobe thickness/volume mediated the relationship of WMH volume on global cognition and memory functioning. The mediating relationship was similar across racial and ethnic groups and across diagnostic groups (i.e., mild cognitive impairment/Alzheimer's disease). The findings suggest that WMH promote atrophy, which, in turn, drives cognitive decline and highlight a potential pathway in which small vessel cerebrovascular disease affects cognition by promoting neurodegenerative changes directly.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neurobiology of Aging - Volume 64, April 2018, Pages 25-32
Journal: Neurobiology of Aging - Volume 64, April 2018, Pages 25-32
نویسندگان
Batool Rizvi, Atul Narkhede, Briana S. Last, Mariana Budge, Giuseppe Tosto, Jennifer J. Manly, Nicole Schupf, Richard Mayeux, Adam M. Brickman,