کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6803005 | 1433519 | 2018 | 43 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
GABA levels and measures of intracortical and interhemispheric excitability in healthy young and older adults: an MRS-TMS study
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کلمات کلیدی
Gamma-aminobutyric acid (GABA) - اسید گاما آمینو بوتیریک (GABA)Transcranial magnetic stimulation (TMS) - تحریک مغناطیسی ترانس مغناطیسی (TMS)Aging - سالخوردگیMagnetic resonance spectroscopy (MRS) - طیف سنجی رزونانس مغناطیسی (MRS)interhemispheric inhibition - مهار interemisphericIntracortical inhibition - مهار intracortical
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
سالمندی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: GABA levels and measures of intracortical and interhemispheric excitability in healthy young and older adults: an MRS-TMS study GABA levels and measures of intracortical and interhemispheric excitability in healthy young and older adults: an MRS-TMS study](/preview/png/6803005.png)
چکیده انگلیسی
Edited magnetic resonance spectroscopy (MRS) and transcranial magnetic stimulation (TMS) have often been used to study the integrity of the GABAergic neurotransmission system in healthy aging. To investigate whether the measurement outcomes obtained with these 2 techniques are associated with each other in older human adults, gamma-aminobutyric acid (GABA) levels in the left sensorimotor cortex were assessed with edited MRS in 28 older (63-74Â years) and 28 young adults (19-34Â years). TMS at rest was then used to measure intracortical inhibition (short-interval intracortical inhibition/long-interval intracortical inhibition), intracortical facilitation, interhemispheric inhibition from left to right primary motor cortex (M1) and recruitment curves of left and right M1. Our observations showed that short-interval intracortical inhibition and long-interval intracortical inhibition in the left M1 were reduced in older adults, while GABA levels did not significantly differ between age groups. Furthermore, MRS-assessed GABA within left sensorimotor cortex was not correlated with TMS-assessed cortical excitability or inhibition. These observations suggest that healthy aging gives rise to altered inhibition at the postsynaptic receptor level, which does not seem to be associated with MRS-assessed GABA+ levels.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neurobiology of Aging - Volume 65, May 2018, Pages 168-177
Journal: Neurobiology of Aging - Volume 65, May 2018, Pages 168-177
نویسندگان
Lize Hermans, Oron Levin, Celine Maes, Peter van Ruitenbeek, Kirstin-Friederike Heise, Richard A.E. Edden, Nicolaas A.J. Puts, Ronald Peeters, Bradley R. King, Raf L.J. Meesen, Inge Leunissen, Stephan P. Swinnen, Koen Cuypers,