کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6803153 | 1433522 | 2018 | 34 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Genetic influence of plasma homocysteine on Alzheimer's disease
ترجمه فارسی عنوان
اثر ژنتیکی هموسیستئین پلاسمی بر بیماری آلزایمر
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کلمات کلیدی
تصادفی منگل، بیماری آلزایمر، سالخورده، هموسیستئین پلاسما، انجمن علمی، نمره پولی ژنیک،
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
سالمندی
چکیده انگلیسی
Observational studies have consistently reported elevated plasma homocysteine as a risk factor for Alzheimer's disease (AD). However, results from clinical trials of homocysteine-lowering treatments are inconsistent. This discrepancy may be explained by a lack of causal association between homocysteine and AD. Mendelian randomization studies have the potential to provide insight into the causality of this association through studying the effect of genetic predisposition to high homocysteine on AD. Our analyses using summarized (n = 54,162) and individual participant (n = 6987) data from Caucasian participants did not show an effect of plasma homocysteine genetic risk on susceptibility to AD. Although with smaller sample sizes, further subanalyses also did not support an effect of genetically determined plasma homocysteine on cognitive impairment and decline, beta-amyloid and tau pathology and gray matter atrophy in AD. However, we found associations with tau tangle burden (n = 251) and gray matter atrophy (n = 605) in cognitively normal elderly. Our results do not support a causal association between elevated homocysteine and risk, severity, and progression of AD. However, the relationship between genetically determined homocysteine and brain pathology in cognitively normal elderly requires further exploration.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neurobiology of Aging - Volume 62, February 2018, Pages 243.e7-243.e14
Journal: Neurobiology of Aging - Volume 62, February 2018, Pages 243.e7-243.e14
نویسندگان
Tina Roostaei, Daniel Felsky, Arash Nazeri, Philip L. De Jager, Julie A. Schneider, David A. Bennett, Aristotle N. Voineskos, Alzheimer's Disease Neuroimaging Initiative Alzheimer's Disease Neuroimaging Initiative,