کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6803346 | 1433539 | 2016 | 45 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Spatial training promotes short-term survival and neuron-like differentiation of newborn cells in Aβ1-42-injected rats
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
سالمندی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Spatial training promotes short-term survival and neuron-like differentiation of newborn cells in Aβ1-42-injected rats Spatial training promotes short-term survival and neuron-like differentiation of newborn cells in Aβ1-42-injected rats](/preview/png/6803346.png)
چکیده انگلیسی
Neurogenesis plays a role in hippocampus-dependent learning and impaired neurogenesis may correlate with cognitive deficits in Alzheimer's disease. Spatial training influences the production and fate of newborn cells in hippocampus of normal animals, whereas the effects on neurogenesis in Alzheimer-like animal are not reported until now. Here, for the first time, we investigated the effect of Morris water maze training on proliferation, survival, apoptosis, migration, and differentiation of newborn cells in β-amyloid-treated Alzheimer-like rats. We found that spatial training could preserve a short-term survival of newborn cells generated before training, during the early phase, and the late phase of training. However, the training had no effect on the long-term survival of mature newborn cells generated at previously mentioned 3 different phases. We also demonstrated that spatial training promoted newborn cell differentiation preferentially to the neuron direction. These findings suggest a time-independent neurogenesis induced by spatial training, which may be indicative for the cognitive stimulation in Alzheimer's disease therapy.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neurobiology of Aging - Volume 45, September 2016, Pages 64-75
Journal: Neurobiology of Aging - Volume 45, September 2016, Pages 64-75
نویسندگان
Juan Zeng, Xia Jiang, Xian-Feng Hu, Rong-Hong Ma, Gao-Shang Chai, Dong-Sheng Sun, Zhi-Peng Xu, Li Li, Jian Bao, Qiong Feng, Yu Hu, Jiang Chu, Da-min Chai, Xiao-Yue Hong, Jian-Zhi Wang, Gong-Ping Liu,