کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6803497 1433543 2016 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Environmental enrichment preserved lifelong ocular dominance plasticity, but did not improve visual abilities
ترجمه فارسی عنوان
غنی سازی محیط زیست باعث حفظ انعطاف پذیری چشم در طول عمر انسان می شود، اما توانایی های بصری را بهبود نمی بخشد
کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی سالمندی
چکیده انگلیسی
In standard cage (SC)-raised mice, ocular dominance (OD) plasticity of the primary visual cortex (V1) induced by monocular deprivation (MD) is maximal in juveniles, declines in adults, and is absent beyond postnatal day (PD) 110. Raising mice in an enriched environment (EE) preserved a juvenile-like OD plasticity after 7 days of MD until at least PD196, mediated by reductions of deprived eye responses in V1. Whether the sensitive phase for OD plasticity can be prolonged into older age and whether long-term EE modifies visual abilities was not yet known. Here, we demonstrate that EE raising enables lifelong OD plasticity. In contrast to PD200 EE-mice, the preserved OD shift in both >PD400 and >PD700 EE-mice was mediated by increases in open eye responses in V1 (adult OD plasticity). When SC-mice were transferred to EE after PD110, OD plasticity was restored until PD922. Moreover, visual abilities tested by both optomotry and the visual water task and interindividual variability were not different between PD700 SC- and EE-mice. Taken together, EE raising enabled a lifelong OD plasticity but did not affect basic visual performance.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neurobiology of Aging - Volume 41, May 2016, Pages 130-137
نویسندگان
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