کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6803747 | 1433549 | 2015 | 11 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Suspected non-AD pathology in mild cognitive impairment
ترجمه فارسی عنوان
آسیب شناسی غیر آدمی در اختلال شناختی خفیف
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
سالمندی
چکیده انگلیسی
We aim to better characterize mild cognitive impairment (MCI) patients with suspected non-Alzheimer's disease (AD) pathology (SNAP) based on their longitudinal outcome, cognition, biofluid, and neuroimaging profile. MCI participants (n = 361) from ADNI-GO/2 were designated “amyloid positive” with abnormal amyloid-beta 42 levels (AMY+) and “neurodegeneration positive” (NEU+) with abnormal hippocampal volume or hypometabolism using fluorodeoxyglucose-positron emission tomography. SNAP was compared with the other MCI groups and with AMYâ controls. AMYâNEU+/SNAP, 16.6%, were older than the NEUâ groups but not AMYâ controls. They had a lower conversion rate to AD after 24 months than AMY+NEU+ MCI participants. SNAP-MCI participants had similar amyloid-beta 42 levels, florbetapir and tau levels, but larger white matter hyperintensity volumes than AMYâ controls and AMYâNEUâ MCI participants. SNAP participants performed worse on all memory domains and on other cognitive domains, than AMYâNEUâ participants but less so than AMY+NEU+ participants. Subthreshold levels of cerebral amyloidosis are unlikely to play a role in SNAP-MCI, but pathologies involving the hippocampus and cerebrovascular disease may underlie the neurodegeneration and cognitive impairment in this group.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neurobiology of Aging - Volume 36, Issue 12, December 2015, Pages 3152-3162
Journal: Neurobiology of Aging - Volume 36, Issue 12, December 2015, Pages 3152-3162
نویسندگان
Laura E.M. Wisse, Nirali Butala, Sandhitsu R. Das, Christos Davatzikos, Bradford C. Dickerson, Sanjeev N. Vaishnavi, Paul A. Yushkevich, David A. Wolk, Alzheimer's Disease Neuroimaging Initiative Alzheimer's Disease Neuroimaging Initiative,