کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6803980 1433551 2015 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Candidate genes for Alzheimer's disease are associated with individual differences in plasma levels of beta amyloid peptides in adults with Down syndrome
ترجمه فارسی عنوان
ژن های نامشخص برای بیماری آلزایمر با تفاوت های فردی در سطح پلاسمای پپتیدهای بتا آمیلوئید در بزرگسالان مبتلا به سندرم داون
کلمات کلیدی
سندرم داون، پپتیدهای آمیلوئید ²، ژنتیک، بیومارکرها،
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی سالمندی
چکیده انگلیسی
We examined the contribution of candidates genes for Alzheimer's disease (AD) to individual differences in levels of beta amyloid peptides in adults with Down syndrom, a population at high risk for AD. Participants were 254 non-demented adults with Down syndrome, 30-78 years of age. Genomic deoxyribonucleic acid was genotyped using an Illumina GoldenGate custom array. We used linear regression to examine differences in levels of Aβ peptides associated with the number of risk alleles, adjusting for age, sex, level of intellectual disability, race and/or ethnicity, and the presence of the APOE ε4 allele. For Aβ42 levels, the strongest gene-wise association was found for a single nucleotide polymorphism (SNP) on CAHLM1; for Aβ40 levels, the strongest gene-wise associations were found for SNPs in IDE and SOD1, while the strongest gene-wise associations with levels of the Aβ42/Aβ40 ratio were found for SNPs in SORCS1. Broadly classified, variants in these genes may influence amyloid precursor protein processing (CALHM1, IDE), vesicular trafficking (SORCS1), and response to oxidative stress (SOD1).
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neurobiology of Aging - Volume 36, Issue 10, October 2015, Pages 2907.e1-2907.e10
نویسندگان
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