کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6803993 | 1433552 | 2015 | 12 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Cd59a deficiency in mice leads to preferential innate immune activation in the retinal pigment epithelium-choroid with age
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موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
سالمندی
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![عکس صفحه اول مقاله: Cd59a deficiency in mice leads to preferential innate immune activation in the retinal pigment epithelium-choroid with age Cd59a deficiency in mice leads to preferential innate immune activation in the retinal pigment epithelium-choroid with age](/preview/png/6803993.png)
چکیده انگلیسی
Dysregulation of the complement system has been implicated in the pathogenesis of age-related macular degeneration. To investigate consequences of altered complement regulation in the eye with age, we examined Cd59a complement regulator deficient (Cd59aâ/â) mice between 4 and 15 months. In vivo imaging revealed an increased age-related accumulation of autofluorescent spots in Cd59aâ/â mice, a feature that reflects accumulation of subretinal macrophages and/or microglia. Despite this activation of myeloid cells in the eye, Cd59aâ/â mice showed normal retinal histology and function as well as normal choroidal microvasculature. With age, they revealed increased expression of activators of the alternative complement pathway (C3, Cfb, Cfd), in particular in the retinal pigment epithelium (RPE)-choroid but less in the retina. This molecular response was not altered by moderately-enhanced light exposure. Cd59a deficiency therefore leads to a preferential age-related dysregulation of the complement system in the RPE-choroid, that alone or in combination with light as a trigger, is not sufficient to cause choroidal vascular changes or retinal degeneration and dysfunction. This data emphasizes the particular vulnerability of the RPE-choroidal complex to dysregulation of the alternative complement pathway during aging.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neurobiology of Aging - Volume 36, Issue 9, September 2015, Pages 2637-2648
Journal: Neurobiology of Aging - Volume 36, Issue 9, September 2015, Pages 2637-2648
نویسندگان
Philipp Herrmann, Jill A. Cowing, Enrico Cristante, Sidath E. Liyanage, Joana Ribeiro, Yanai Duran, Laura Abelleira Hervas, Livia S. Carvalho, James W.B. Bainbridge, Ulrich F.O. Luhmann, Robin R. Ali,