کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6804321 1433557 2015 32 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Stuck in default mode: inefficient cross-frequency synchronization may lead to age-related short-term memory decline
ترجمه فارسی عنوان
در حالت پیش فرض گیر افتاده است: هماهنگ سازی فرکانس متقاطع ناکارآمد ممکن است منجر به کاهش حافظه کوتاه مدت حافظه شود
کلمات کلیدی
هماهنگ سازی متقابل فرکانس، نوسانات، پیری طبیعی شبکه های مغز، حافظه کوتاه مدت،
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی سالمندی
چکیده انگلیسی
Aging-related decline in short-term memory capacity seems to be caused by deficient balancing of task-related and resting state brain networks activity; however, the exact neural mechanism underlying this deficit remains elusive. Here, we studied brain oscillatory activity in healthy young and old adults during visual information maintenance in a delayed match-to-sample task. Particular emphasis was on long range phase:amplitude coupling of frontal alpha (8-12 Hz) and posterior fast oscillatory activity (>30 Hz). It is argued that through posterior fast oscillatory activity nesting into the excitatory or the inhibitory phase of frontal alpha wave, long-range networks can be efficiently coupled or decoupled, respectively. On the basis of this mechanism, we show that healthy, elderly participants exhibit a lack of synchronization in task-relevant networks while maintaining synchronized regions of the resting state network. Lacking disconnection of this resting state network is predictive of aging-related short-term memory decline. These results support the idea of inefficient orchestration of competing brain networks in the aging human brain and identify the neural mechanism responsible for this control breakdown.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neurobiology of Aging - Volume 36, Issue 4, April 2015, Pages 1611-1618
نویسندگان
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