کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6804960 1433560 2015 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Age-associated evolution of plasmatic amyloid in mouse lemur primates: relationship with intracellular amyloid deposition
ترجمه فارسی عنوان
تحولات مرتبط با سن آمیلوئید پلاسمایی در پستانداران مائور موش: ارتباط با رسوب آمیلوئید داخل سلولی
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی سالمندی
چکیده انگلیسی
Alzheimer's disease (AD) is the most common age-related neurodegenerative disorder. Amyloid-β peptide (Aβ) deposition in the brain is one of its hallmarks, and the measure of plasma Aβ is considered to be a biomarker for anti-amyloid drug efficacy in animal models of AD. However, age-associated plasmatic Aβ modulation in animal models is practically never addressed in the literature. Mouse lemur primates are used as a model of normal and AD-like cerebral aging. Here, we studied the effect of age on plasmatic Aβ in 58 mouse lemurs aged from 1 to 10 years. A subset of animals presented high plasmatic Aβ, and the proportion of animals with high plasmatic Aβ was higher in aged animals as compared with young ones. Histologic evaluation of the brain of some of these animals was carried out to assess extracellular and intracellular amyloid load. In aged lemurs, plasmatic Aβ was negatively correlated with the density of neurons accumulating deposits of Aβ.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neurobiology of Aging - Volume 36, Issue 1, January 2015, Pages 149-156
نویسندگان
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