کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6805436 | 1433563 | 2014 | 38 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Enhanced defense against mitochondrial hydrogen peroxide attenuates age-associated cognition decline
ترجمه فارسی عنوان
دفاع پیشرفته در برابر پراکسید هیدروژن میتوکندری موجب کاهش شناخت شناختی مرتبط با سن می شود
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
سالمندی
چکیده انگلیسی
Increased mitochondrial hydrogen peroxide (H2O2) is associated with Alzheimer's disease and brain aging. Peroxiredoxin 3 (Prdx3) is the key mitochondrial antioxidant defense enzyme in detoxifying H2O2. To investigate the importance of mitochondrial H2O2 in age-associated cognitive decline, we compared cognition between aged (17-19Â months) APP transgenic mice and APP/Prdx3 double transgenic mice (dTG) and between old (24Â months) wild-type mice and Prdx3 transgenic mice (TG). Compared with aged APP mice, aged dTG mice showed improved cognition that was correlated with reduced brain amyloid beta levels and decreased amyloid beta production. Old TG mice also showed significantly increased cognitive ability compared with old wild-type mice. Both aged dTG mice and old TG mice had reduced mitochondrial oxidative stress and increased mitochondrial function. Moreover, CREB signaling, a signaling pathway important for cognition was enhanced in both aged dTG mice and old TG mice. Thus, our results indicate that mitochondrial H2O2 is a key culprit of age-associated cognitive impairment, and that a reduction of mitochondrial H2O2 could improve cognition by maintaining mitochondrial health and enhancing CREB signaling.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neurobiology of Aging - Volume 35, Issue 11, November 2014, Pages 2552-2561
Journal: Neurobiology of Aging - Volume 35, Issue 11, November 2014, Pages 2552-2561
نویسندگان
Liuji Chen, Ren Na, Qitao Ran,