کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6805477 | 1433563 | 2014 | 31 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Seizure resistance without parkinsonism in aged mice after tau reduction
ترجمه فارسی عنوان
مقاومت در برابر تشنج بدون پارکینسونی در موش سوری پس از کاهش تئو
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کلمات کلیدی
تاو، تصرف، صرع، هیجان انگیز، پارکینسونیسم، بیماری آلزایمر، میکروتوبول،
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
سالمندی
چکیده انگلیسی
Tau is an emerging target for Alzheimer's disease (AD) and other conditions with epileptiform activity. Genetic tau reduction (in Tau+/â and Tauâ/â mice) prevents deficits in AD models and has an excitoprotective effect, increasing resistance to seizures, without causing apparent neuronal dysfunction. However, most studies of tau reduction have been conducted in <1-year-old mice, and the effects of tau reduction in aged mice are less clear. Specifically, whether the excitoprotective effects of tau reduction persist with aging is unknown and whether tau reduction causes neuronal dysfunction, including parkinsonism, with aging is controversial. Here, we performed a comprehensive analysis of 2-year-old Tau+/+, Tau+/â, and Tauâ/â mice. In aged mice, tau reduction still conferred resistance to pentylenetetrazole-induced seizures. Moreover, tau reduction did not cause parkinsonian abnormalities in dopamine levels or motor function and did not cause iron accumulation or impaired cognition, although Tauâ/â mice had mild hyperactivity and decreased brain weight. Importantly, the excitoprotective effect in aged Tau+/â mice was not accompanied by detectable abnormalities, indicating that partially reducing tau or blocking its function may be a safe and effective therapeutic approach for AD and other conditions with increased excitability.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neurobiology of Aging - Volume 35, Issue 11, November 2014, Pages 2617-2624
Journal: Neurobiology of Aging - Volume 35, Issue 11, November 2014, Pages 2617-2624
نویسندگان
Zhiyong Li, Alicia M. Hall, Mark Kelinske, Erik D. Roberson,