کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6806031 1433569 2014 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Latent Toxoplasma gondii infection leads to deficits in goal-directed behavior in healthy elderly
ترجمه فارسی عنوان
آلودگی به توکسوپلاسما گوندی به صورت نقص در رفتار هدفمند در سالمندان سالمند منجر می شود
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی سالمندی
چکیده انگلیسی
Goal-directed behavior is well-known to show declines in elderly individuals, possibly because of alterations in dopaminergic neural transmission. The dopaminergic system is modulated by a number of other different factors. One of these factors, which has attracted a considerable amount of interest in neurobiology, but has only rarely been examined with respect to its possible modulatory role for cognitive functions in elderly individuals, is latent Toxoplasma gondii (T. gondii) infection. Latent T. gondii infection may be of relevance to goal-directed behavior as it alters dopaminergic neural transmission. We examine goal-directed behavior in T. gondii IgG positive and negative elderly subjects in auditory distraction paradigm. We apply event-related potentials to examine which cognitive subprocesses are affected by latent T. gondii infection on a neurophysiological level. We show that latent T. gondii infection compromises the management of auditory distraction in elderly by specifically delaying processes of attentional allocation and disengagement. The results show that latent T. gondii infection is neglected but an important neurobiological modulator of cognitive functions in elderly individuals.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neurobiology of Aging - Volume 35, Issue 5, May 2014, Pages 1037-1044
نویسندگان
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