کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6807139 | 1433579 | 2013 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Effects of a high-fat, high-cholesterol diet on brain lipid profiles in apolipoprotein E É3 and É4 knock-in mice
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
سالمندی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Effects of a high-fat, high-cholesterol diet on brain lipid profiles in apolipoprotein E É3 and É4 knock-in mice Effects of a high-fat, high-cholesterol diet on brain lipid profiles in apolipoprotein E É3 and É4 knock-in mice](/preview/png/6807139.png)
چکیده انگلیسی
Apolipoprotein E (ApoE) is important in facilitating the transport of lipids (cholesterol, phospholipids, and sulfatides) and plays a fundamental role in normal lipid metabolism. High cholesterol levels increases the risk of developing Alzheimer's disease. In this study, we investigated the effects of a high-fat high cholesterol (HFHC) diet on brain lipid profiles in 95 young and aged APOE É3 and É4 knock-in mice to determine whether diet leads to altered brain levels of a number of glycerophospholipids, sphingolipids, cholesterol precursors, cholesterol, cholesterol oxidation products, and cholesterol esters. The results in this study revealed significant changes in lipid levels. The HFHC-enriched diet influenced the levels of cholesterol esters. A sharp increase in cholesterol ester levels, particularly in the aged APOE É4 diet-enriched group, might be suggestive of abnormal acyl-coenzyme A:cholesterol acyltransferase 1 (ACAT) activity and/or levels. Age exerts appreciable effects on the brain lipidome, especially with regard to polar lipid species.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neurobiology of Aging - Volume 34, Issue 9, September 2013, Pages 2217-2224
Journal: Neurobiology of Aging - Volume 34, Issue 9, September 2013, Pages 2217-2224
نویسندگان
Wei Ling Florence Lim, Sin Man Lam, Guanghou Shui, Alinda Mondal, Daniel Ong, Xinrui Duan, Rhona Creegan, Ian J. Martins, Matthew J. Sharman, Kevin Taddei, Giuseppe Verdile, Markus R. Wenk, Ralph Nigel Martins,