کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6807262 | 1433581 | 2013 | 12 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Striatal morphology in early-onset and late-onset Alzheimer's disease: a preliminary study
ترجمه فارسی عنوان
مورفولوژی استرادیلی در ابتدای شروع بیماری و شروع بیماری آلزایمر: مطالعات اولیه
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
سالمندی
چکیده انگلیسی
We investigated volume and shape changes in the striatum (caudate, putamen, and nucleus accumbens) of 18 early-onset (EOAD) and 18 late-onset (LOAD) Alzheimer's Disease patients compared with 2 control groups age- and sex-matched to each patient group, and explored the relationship between striatal atrophy and apolipoprotein E (APOE) genotype. EOAD patients showed significant shape changes in the left and right ventral putamen (p < 0.05, corrected for multiple comparison with permutation tests). LOAD patients showed significant reductions in the left and right nucleus accumbens volumes (p < 0.05; Mann-Whitney test) and shape (p < 0.05; permutation test). Caudate abnormalities were detected in EOAD and LOAD patients in terms of local enlargements and reductions (p < 0.05 for the left and right, permutation test). When APOE was considered, significant differences were detected between LOAD ε4 carriers and noncarriers in the left and right caudate (p < 0.05, permutation test). These results suggest distinct patterns of striatal pathology in EOAD and LOAD patients, the dorsal striatum being involved in EOAD and the ventral striatum in LOAD.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neurobiology of Aging - Volume 34, Issue 7, July 2013, Pages 1728-1739
Journal: Neurobiology of Aging - Volume 34, Issue 7, July 2013, Pages 1728-1739
نویسندگان
Michela Pievani, Martina Bocchetta, Marina Boccardi, Enrica Cavedo, Matteo Bonetti, Paul M. Thompson, Giovanni B. Frisoni,