کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6807468 | 1433583 | 2013 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Distinctive age-related temporal cortical thinning in asymptomatic granulin gene mutation carriers
ترجمه فارسی عنوان
نازک شدن قشر زمانی مشخص در حامل های جهش گرانولی بدون علامت
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
سالمندی
چکیده انگلیسی
Studies in asymptomatic granulin gene (GRN) mutation carriers are essential to improve our understanding of the pattern and timing of early morphologic brain changes in frontotemporal lobar degeneration. The main objectives of this study were to assess the effect of age in cortical thickness changes (CTh) in preclinical GRN mutation carriers and to study the relationship of CTh with cognitive performance in GRN mutation carriers. We calculated CTh maps in 13 asymptomatic carriers of the c.709-1G>A GRN mutation and 13 age- and sex-matched healthy subjects. Asymptomatic GRN mutation carriers presented different patterns of age-related cortical thinning in the right superior temporal and middle temporal gyri and the banks of the superior temporal sulcus bilaterally when compared with controls. Cortical thickness was correlated with neuropsychological test scores: Trail Making Tests A and B, and the Boston Naming Test. Distinctive age-related cortical thinning in asymptomatic GRN mutation carriers in lateral temporal cortices suggests an early and disease-specific effect in these areas.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neurobiology of Aging - Volume 34, Issue 5, May 2013, Pages 1462-1468
Journal: Neurobiology of Aging - Volume 34, Issue 5, May 2013, Pages 1462-1468
نویسندگان
FermÃn Moreno, Roser Sala-Llonch, Myriam Barandiaran, Raquel Sánchez-Valle, Ainara Estanga, David Bartrés-Faz, Andone Sistiaga, Ainhoa Alzualde, Esther Fernández, José Félix Martà Massó, Adolfo López de Munain, Begoña Indakoetxea,