کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6807874 | 1433587 | 2013 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Visual ratings of atrophy in MCI: prediction of conversion and relationship with CSF biomarkers
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
Alzheimer's Disease Neuroimaging Initiative (ADNI)Visual rating scalesMedial temporal lobe atrophy - آتروفی لوب مادیMild cognitive impairment (MCI) - اختلال شناختی خفیف (MCI)Magnetic Resonance Imaging (MRI) - امآرآیAlzheimer's disease (AD) - بیماری آلزایمر (AD)Conversion - تبدیلCerebrospinal fluid (CSF) - مایع مغزی نخاعی (CSF)Biomarkers - نشانگر زیستی یا بیومارکر
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
سالمندی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Visual ratings of atrophy in MCI: prediction of conversion and relationship with CSF biomarkers Visual ratings of atrophy in MCI: prediction of conversion and relationship with CSF biomarkers](/preview/png/6807874.png)
چکیده انگلیسی
Medial temporal lobe atrophy (MTA) and cerebrospinal fluid (CSF) markers of Alzheimer's disease (AD) pathology may aid the early detection of AD in mild cognitive impairment (MCI). However, the relationship between structural and pathological markers is not well understood. Furthermore, while posterior atrophy (PA) is well recognized in AD, its value in predicting conversion from late-onset amnestic MCI to AD is unclear. In this study we used visual ratings of MTA and PA to assess their value in predicting conversion to AD in 394 MCI patients. The relationship of atrophy patterns with CSF Aβ1-42, tau, and p-tau(181) was further investigated in 114 controls, 192 MCI, and 99 AD patients. There was a strong association of MTA ratings with conversion to AD (p < 0.001), with a weaker association for PA ratings (p = 0.047). Specific associations between visual ratings and CSF biomarkers were found; MTA was associated with lower levels of Aβ1-42 in MCI, while PA was associated with elevated levels of tau in MCI and AD, which may reflect widespread neuronal loss including posterior regions. These findings suggest both that posterior atrophy may predict conversion to AD in late-onset MCI, and that there may be differential relationships between CSF biomarkers and regional atrophy patterns.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neurobiology of Aging - Volume 34, Issue 1, January 2013, Pages 73-82
Journal: Neurobiology of Aging - Volume 34, Issue 1, January 2013, Pages 73-82
نویسندگان
Manja Lehmann, Esther L. Koedam, Josephine Barnes, Jonathan W. Bartlett, Frederik Barkhof, Mike P. Wattjes, Jonathan M. Schott, Philip Scheltens, Nick C. Fox, Alzheimer's Disease Neuroimaging Initiative Alzheimer's Disease Neuroimaging Initiative,