کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6807968 | 1433588 | 2012 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Determinants of cerebellar and cerebral volume in the general elderly population
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کلمات کلیدی
Infarcts - انفارکتCerebrovascular disease - بیماری عروق مغزیMagnetic resonance imaging - تصویربرداری رزونانس مغناطیسیbrain volume - حجم مغزAging - سالخوردگیWhite matter lesions - ضایعات ماده سفیدCardiovascular risk factors - عوامل خطر قلبی عروقیCerebellum - مخچهCohort study - مطالعه کوهورت یا هم گروهیCerebrum - مغز
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
سالمندی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
In a population-based study of 3962 community-dwelling nondemented elderly we investigated the relation of age, sex, cardiovascular risk factors, and the presence of infarcts with cerebellar volume, and its interrelationship with cerebral volumes. Cerebellar and cerebral gray and white matter were segmented using Freesurfer version 4.5 (http://surfer.nmr.mgh.harvard.edu/). We used linear regression analyses to model the relationship between age, sex, cardiovascular risk factors, brain infarcts, white matter lesions (WMLs) and cerebellar and cerebral volume. Smaller cerebellar volumes with increasing age were mainly driven by loss of white matter. Diabetes, higher serum glucose and lower cholesterol levels were related to smaller cerebellar volume. No association was found between hypertension, smoking, apolipoprotein E (ApoE) genotype, and cerebellar volume. Supratentorial lacunar infarcts and WMLs were related to smaller cerebellar volume. Infratentorial infarcts were related to smaller cerebellar white matter volume and total cerebral volume. This study suggests that determinants of cerebellar volume do not entirely overlap with those established for cerebral volume. Furthermore, presence of infarcts or WMLs in the cerebrum can affect cerebellar volume.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neurobiology of Aging - Volume 33, Issue 12, December 2012, Pages 2774-2781
Journal: Neurobiology of Aging - Volume 33, Issue 12, December 2012, Pages 2774-2781
نویسندگان
Yoo Young Hoogendam, Jos N. van der Geest, Fedde van der Lijn, Aad van der Lugt, Wiro J. Niessen, Gabriel P. Krestin, Albert Hofman, Meike W. Vernooij, Monique M.B. Breteler, M. Arfan Ikram,