کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6808398 | 1433591 | 2012 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Targeting NR2A-containing NMDA receptors reduces L-DOPA-induced dyskinesias
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
سالمندی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Targeting NR2A-containing NMDA receptors reduces L-DOPA-induced dyskinesias Targeting NR2A-containing NMDA receptors reduces L-DOPA-induced dyskinesias](/preview/png/6808398.png)
چکیده انگلیسی
Levodopa (L-DOPA)-induced dyskinesias represent the main side effect of the therapeutic strategy clinically used in Parkinson's disease (PD) treatment. The first beneficial “honeymoon” phase of L-DOPA therapy is followed by a phase of deterioration in which L-DOPA administration causes motor fluctuations in the drug efficacy (“on-off” state) and dyskinesias. Alterations of the composition and function of N-methyl-D-aspartate (NMDA) receptor represent one of the main causes for the striatal synaptic changes described in experimental model of dyskinesias. In the present study, the modulation of the composition of synaptic NMDA receptor by using a cell-permeable peptide targeting NR2A subunit during the development of dyskinesias led to a reduction of the percentage of parkinsonian rats developing dyskinetic movements.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neurobiology of Aging - Volume 33, Issue 9, September 2012, Pages 2138-2144
Journal: Neurobiology of Aging - Volume 33, Issue 9, September 2012, Pages 2138-2144
نویسندگان
Fabrizio Gardoni, Carmelo Sgobio, Valentina Pendolino, Paolo Calabresi, Monica Di Luca, Barbara Picconi,