کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6810140 1433602 2011 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Cholinergic axon length reduced by 300 meters in the brain of an Alzheimer mouse model
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی سالمندی
پیش نمایش صفحه اول مقاله
Cholinergic axon length reduced by 300 meters in the brain of an Alzheimer mouse model
چکیده انگلیسی
Modern stereological techniques have been used to show that the total length of the cholinergic fibers in the cerebral cortex of the APPswe/PS1deltaE9 mouse is reduced by almost 300 meters at 18 months of age and has a nonlinear relationship to the amount of transgenetically-induced amyloidosis. These data provide rigorous quantitative morphological evidence that Alzheimer's-like amyloidosis affects the axons of the cholinergic enervation of the cerebral cortex.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neurobiology of Aging - Volume 32, Issue 11, November 2011, Pages 1927-1931
نویسندگان
, , ,