Keywords: Airway inflammation; Airway remodeling; Anti-muscarinic drug; Cholinergic regulation; Non-neuronal ACh; ACh; acetylcholine; ASM; airway smooth muscle; cAMP; cyclic adenosine monophosphate; ChAT; choline acetyltransferase; CHT1; high-affinity choline trans
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Keywords: Sudomotor function; ESC; Skin biopsy; Neuropathic pain; Dysautonomia; ANS; autonomic nervous system; CGRP; calcitonin gene-related peptide; Cy3; cyanine 3.18; ESC; electrochemical skin conductance; IENF; intraepidermal nerve fibre; IENFD; intraepidermal n
Keywords: 5-HT; serotonin (5-hydroxytryptamine); A83-01; TGF-β kinase/activin receptor-like kinase inhibitor; ACTB; actin beta/beta-actin; ASCL1; achaete-scute homolog 1 (MASH1); ASOs; anti-sense oligonucleotides; Bcl-xL; b-cell lymphoma-extra large; BDNF; brain d
Keywords: Actb; beta-actin; AMED; amniotic membrane matrix-based ES-cell differentiation; AP; action potential; DMEM; Dulbecco's modified eagle medium; DPBS; Dulbecco's phosphate-buffered saline; EB; embryoid body; Egfp; enhanced green fluorescent protein; ES-cell,
Keywords: Lead exposure; Neurotoxicity; Lipid peroxide; Apoptosis; TNFα; PSD-95; SNAP-25; BDNF; TrkB; VAChT
Keywords: ACh; acetylcholine; AChE; acetylcholinesterase; BChE; butyrylcholinesterase; ChAT; choline acetyltransferase; CHT1; choline high affinity transporter; CTL; choline-transporter like protein; EFS; electrical field stimulation; HC-3; hemicholinium-3; VAChT;
Keywords: Ach; acetylcholine; AChE; acetylcholinesterase; ChAT; acetylcholine transferase; VAChT; vesicular acetylcholine transporter; GFAP; glial fibrillary acidic protein; DMSO; dimethylsulphoxide; EMEM; Eagle's minimum essential medium; FBS; fetal bovine serum
Keywords: 5HT; serotonin; 5HT1A; serotonin-1A receptor; ACh; acetylcholine; cAMP; cyclic adenosine monophosphate; ChAT; choline acetyl transferase; DRN; dorsal raphe nucleus; GABA; gamma aminobutyric acid; GAD; glutamic acid decarboxylase; LDT; lateral dorsal tegme
Keywords: [125I]-αBGT; [125I]-α-bungarotoxin; ACh; acetylcholine; AChE; acetylcholinesterase; ANOVA; analysis of variance; ATR; atropine; CA1; cornus ammonis 1 of hippocampus; DAPC; dystrophin-associated glycoprotein complex; DHBE; dihydro-β-erythroidine; DMD; D
Keywords: AcCoA; acetyl-coenzyme A; ACh; acetylcholine; AChE; acetylcholinesterase; AChR; ACh receptors; AD; Alzheimer's disease; ANS; autonomic nervous system; AThCh; acetylthiocholine; BAPTA-AM; 1,2-bis-(2-aminophenoxy)ethane N,N,N,Nâ²-tetraaceticacid tetra(ac
Keywords: OFC; Orbitofrontal cortex; mPFC; medial prefrontal cortex; ACC; anterior cingulate cortex; NB; nucleus basalis; VTA; ventral tegmental area; DRN; dorsal raphe nucleus; LC; locus coeruleus; VAChT; vesicular acetylcholine transporter; TH; tyrosine hydroxyla
Long-term estradiol-17β exposure decreases the cholinergic innervation pattern of the pig ovary
Keywords: ACh; acetylcholine; CL; corpora lutea; E1; estrone; E2; estradiol-17β; IR; immunoreactive; NaN3; sodium azide; NGF; nerve growth factor; nNOS; nitric oxide synthase; P4; progesterone; PCG; paracervical ganglion; SOM; somatostatin; T; testosterone; VAChT;
Cocaine- and amphetamine-regulated transcript (CART) peptide in the enteric nervous system of the porcine esophagus
Keywords: Co-localization; Enteric neurons; Digestive tract; Immunofluorescence; Pig; CART; cocaine- and amphetamine/regulated transcript peptide; CGRP; calcitonin gene related peptide; CY3; cyanine 3; ENS; enteric nervous system; FITC; fluorescein isothiocyanate;
Variable expression of GFP in different populations of peripheral cholinergic neurons of ChATBAC-eGFP transgenic mice
Keywords: ANS; autonomic nervous system; BSA; bovine serum albumin; ChAT; choline acetyltransferase; pChAT; peripheral choline acetyltransferase; GFP; enhanced green fluorescent protein; NDS; normal donkey serum; PBS; phosphate-buffered saline; VAChT; vesicular ace
TLQP Peptides in Amyotrophic Lateral Sclerosis: Possible Blood Biomarkers with a Neuroprotective Role
Keywords: ALS; Amyotrophic Lateral Sclerosis; ALSFRS-R; ALS Functional Rating Scale-Revised; C3AR; complement component 3a receptor 1; gC1q-R; receptor for the globular heads of c1q; DMEM; Dulbecco's modified Eagle's medium; EDTA; ethylenediaminetetraacetic aci
Acrylamide-induced alterations in the cocaine- and amphetamine-regulated peptide transcript (CART)-like immunoreactivity within the enteric nervous system of the porcine small intestines
Keywords: ACM; acrylamide; CART; cocaine- and amphetamine-regulated peptide transcript; C Group; control group; CNS; central nervous system; CRP; C-reactive protein; ENS; enteric nervous system; GAL; galanin; GI; gastrointestinal; HD Group; high dose group; IL-6; i
Expression of MEGF10 in cholinergic and glutamatergic neurons
Keywords: MEGF10; multiple-EGF like domains 10; ABCA1; ATP binding cassette transporter 1; Aβ42; amyloid-β protein 42; AD; Alzheimer's disease; EMEM; Eagle's minimum essential medium; FBS; fetal bovine serum; GM-CSF; granulocyte macrophage colony stimulating fact
Do spiroindolines have the potential to replace vesamicol as lead compound for the development of radioligands targeting the vesicular acetylcholine transporter?
Keywords: YBQFMGUWXJJOBE-OWOJBTEDSA-N; UJLKLUQGBGSJOO-OWOJBTEDSA-N; DSSGEOKNTGYRDY-OWOJBTEDSA-N; RDXPBCTWNYFBFI-OWOJBTEDSA-N; MTENKAMVZFIDIJ-OWOJBTEDSA-N; WLWBMTWWXNCMJH-OWOJBTEDSA-N; VAChT; Vesamicol; Spiroindolines; PET; Sigma receptors;
Chiral resolution of serial potent and selective Ï1 ligands and biological evaluation of (â)-[18F]TZ3108 in rodent and the nonhuman primate brain
Keywords: calcd; calculated; CH2Cl2; dichloromethane; CNS; central nervous system; DMSO; dimethyl sulfoxide; [3H]DTG; [3H]ditolylguanidine; DTTA; di-p-toluoyl tartaric acid; EBP; emopamil binding protein; ee; enantiomeric excess; EOB; end of bombardment; EtOH; etha
Synthesis and in vitro evaluation of 5-substituted benzovesamicol analogs containing N-substituted amides as potential positron emission tomography tracers for the vesicular acetylcholine transporter
Keywords: ACh; acetylcholine; VAChT; vesicular acetylcholine transporter; PET; positron emission tomography; AD; Alzheimer's disease; PD; Parkinson's disease; vesamicol; (±)-trans-2-(4-phenylpiperidino)cyclohexanol; benzovesamicol; 3-(4-phenyl-piperidin-1-yl)-1,2,
Botulinum neurotoxin type A-cleaved SNAP25 is confined to primary motor neurons and localized on the plasma membrane following intramuscular toxin injection
Keywords: 2D; 2 dimensional; BoNT/A; botulinum neurotoxin type A; ChAT; choline acetyltransferase; CNS; central nervous system; CTB AF-488; cholera toxin B subunit Alexa Fluor 488 conjugate; DAS; digit abduction score; GAD; glutamic acid decarboxylase; GFAP; glial
Immunolocalization of the vesicular acetylcholine transporter in larval and adult Drosophila neurons
Keywords: Acetylcholine; VAChT; Synaptic vesicle; Neurotransmitter; Localization;
Reduced Vesicular Acetylcholine Transporter favors antidepressant behaviors and modulates serotonin and dopamine in female mouse brain
Keywords: VAChT; Acetylcholine; Dopamine; Serotonin; Depression;
Synaptopathic mechanisms of neurodegeneration and dementia: Insights from Huntington's disease
Keywords: 5-HT; 5-hydroxytryptamine; 7,8-DHF; 7,8-dihydroxyflavone; ACh; acetylcholine; AD; adenosine; ADL; activities of daily living; AMPA; α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid; AMPK; 5â²AMP-activated protein kinase; BDNF; brain-derived neurotro
Research reportMice deficient for striatal Vesicular Acetylcholine Transporter (VAChT) display impaired short-term but normal long-term object recognition memory
Keywords: VAChT; Acetylcholine; Striatum; Object recognition; Object location; Memory;
The recombinant C-terminal fragment of tetanus toxin protects against cholinotoxicity by intraseptal injection of β-amyloid peptide (25-35) in rats
Keywords: ACh; acetylcholine; AChE; acetylcholinesterase; A-Cu-Ag; amino-cupric-silver; AD; Alzheimer's disease; Aβ; β amyloid peptide; ChAT; choline acetyltransferase; CNS; central nervous system; Hc-TeTx; C-terminal domain of tetanus toxin; H&E; Hematoxylin a
Everolimus (RAD001) ameliorates vascular cognitive impairment by regulating microglial function via the mTORC1 signaling pathway
Keywords: VaD; vascular dementia; mTORC1; mammalian target of rapamycin complex 1; AD; Alzheimer's disease; ROS; reactive oxygen species; GWAS; genome-wide association study; IFN; interferon; TNF-α; tumor necrosis factor alpha; IL; interleukin; Arg-1; arginase-1;
Voltage-gated calcium channels are abnormal in cultured spinal motoneurons in the G93A-SOD1 transgenic mouse model of ALS
Keywords: ALS; amyotrophic lateral sclerosis; SOD1; superoxide dismutase-1; AMPA; α-amino-3-hydroxy-5-methylisoxazole propionic acid; VGCC; voltage-gated Ca2 + channel; PCCa; persistent Ca2 + current; mSOD1; mutant SOD1; TEA-Cl; tetraethylammonium chloride; 4-AP
Immuno-detection of OCTN1 (SLC22A4) in HeLa cells and characterization of transport function
Keywords: TEA; tetraethylammonium; PLP; pyridoxal 5-phosphate; MTSEA; 2-aminoethyl methanethiosulfonate; VAChT; vesicular acetylcholine transporter; OCT; organic cation transporter; OCTN; organic cation transporter novel; ChT; choline transporter; Transporters; Pro
Acute and long-term exposure to chlorpyrifos induces cell death of basal forebrain cholinergic neurons through AChE variants alteration
Keywords: Ach; achacetylcholine; AChE; acetylcholine esterase; CHT; high-affinity choline transporter; ChAT; acetylcholine transferase; VAChT; vesicular acetylcholine transporter; DMSO; dimethylsulphoxide; DMEM; Dulbecco's Modified Eagle's Medium; FBS; fetal bo
Comparative analyses of the cholinergic locus of ChAT and VAChT and its expression in the silkworm Bombyx mori
Keywords: Cholinergic neuron; ChAT; VAChT; Gene expression; Silkworm
New systematically modified vesamicol analogs and their affinity and selectivity for the vesicular acetylcholine transporter – A critical examination of the lead structure
Keywords: VAChT; Vesamicol; PET; Sigma receptors
Upregulation of Lhx8 increase VAChT expression and ACh release in neuronal cell line SHSY5Y
Keywords: Lhx8; ChAT; VAChT; ACh; SHSY5Y;
GABAA receptors are located in cholinergic terminals in the nucleus pontis oralis of the rat: Implications for REM sleep control
Keywords: ACh; acetylcholine; BZ; benzodiazepine; GABAAR; type-A GABA receptor; GAD67; glutamic acid decarboxylase-67; KCC2; potassium-chloride cotransporter-2; MAP2; microtubule-associated protein 2; PB; phosphate buffer; PnO; oral pontine reticular formation; REM
Drosophila melanogaster as a genetic model system to study neurotransmitter transporters
Keywords: 5HT; 5-hydroxytryptamine (serotonin); ACh; acetylcholine; ASD; autism spectrum disorder; ChT; choline transporter; ChAT; choline acetyl transferase; DA; dopamine; Ddc; dopa decarboxylase; EAAT; excitatory amino acid transporter; GABA; gamma amino butyric
Therapeutic effectiveness of botulinum neurotoxin A: Potent blockade of autonomic transmission by targeted cleavage of only the pertinent SNAP-25
Keywords: SNAREs; Autonomic neurons; Acetylcholine; Neurotherapeutics; ACSF; artificial cerebrospinal fluid; BoNT; botulinum neurotoxin; BoNT/A - G; BoNT type A - G; DAPI; 4â²,6-diamidino-2-phenylindole; HC and HN; C- and N-terminal halves of the toxins' heavy
Functional expression of choline transporter-like protein 1 (CTL1) in small cell lung carcinoma cells: A target molecule for lung cancer therapy
Keywords: ACh; acetylcholine; AChE; acetylcholinesterase; BuChE; butyrylcholinesterase; ChAT; choline acetyltransferase; CHT1; high-affinity choline transporter 1; CTL1; choline transporter-like protein 1; 4-DAMP; 4-diphenylacetoxy-N-methylpiperidine methiodide; D-
Innervation pattern of the preocular human central retinal artery
Keywords: autonomic nervous system; optic nerve; blood flow regulation; NADPH-diaphorase; DBH; ChAT; VAChT
Decreased acetylcholine release delays the consolidation of object recognition memory
Keywords: Acetylcholine; Consolidation; Memory; Object recognition; VAChT
A fluoro versus a nitro derivative—a high-performance liquid chromatography study of two basic analytes with different reversed phases and silica phases as basis for the separation of a positron emission tomography radiotracer
Keywords: VAChT, vesicular acetylcholine transporter; PET, positron emission tomography; PFP, pentafluorophenyl; ACN, acetonitrile; MeOH, methanolBasic analytes; Cationic-exchange; RP phases; Silanol sites; VAChT
Organic cation transporter 2 (SLC22A2), a low-affinity and high-capacity choline transporter, is preferentially enriched on synaptic vesicles in cholinergic neurons
Keywords: Ach; acetylcholine; AchR; acetyl choline receptors; BTX; alpha-bungarotoxin; CA; central autonomic cells; CC; central canal; ChAT; choline acetyltransferase; CNS; central nervous system; Co; cortex; DAB; 3,3â²-diaminobenzidine; DMEM; Dulbecco's modifie
Pyrrolovesamicols—Synthesis, structure and VAChT binding of two 4-fluorobenzoyl regioisomers
Keywords: Pyrrolovesamicol; Vesamicol; VAChT; Pyrrole
Effects of protein kinase A and G inhibitors on hippocampal cholinergic markers expressions in rolipram- and sildenafil-induced spatial memory improvement
Keywords: PKA; PKG; VAChT; ChAT; Rolipram; Sildenafil; Spatial consolidation;
Overexpression of the vesicular acetylcholine transporter increased acetylcholine release in the hippocampus
Keywords: ACh; acetylcholine; AChE; acetylcholinesterase; amyg nu; amygdala nucleus; BCA; bicinchoninic acid; cc; corpus callosum; cDNA; complementary deoxyribonucleic acid; ChAT; choline acetyltransferase; CHT1; high affinity choline transporter; CP; crossing poin
Synthesis, radiofluorination and pharmacological evaluation of a fluoromethyl spirocyclic PET tracer for central Ï1 receptors and comparison with fluoroalkyl homologs
Keywords: DMT; N,N-dimethyltryptamine; MAM; mitochondrion-associated ER membrane; ER; endoplasmatic reticulum; BiP; binding immunoglobulin protein; IP3R; inositol 1,4,5-triphosphate receptor; PET; positron emission tomography; EMP; emopamil-binding protein; VAChT;
Cholinergic axon length reduced by 300 meters in the brain of an Alzheimer mouse model
Keywords: VAChT; Stereology; Space balls; Axons; Fractionator;
Co-expression studies of the orphan carrier protein Slc10a4 and the vesicular carriers VAChT and VMAT2 in the rat central and peripheral nervous system
Keywords: Slc10a4; VAChT; VMAT2; synaptic vesicles; transportAsbt, apical sodium-dependent bile acid transporter; BAC, bacterial artificial chromosome; BSA, bovine serum albumin; ChAT, choline acetyltransferase; CHT1, high affinity choline transporter; CVF, crude v
Accessible silanol sites – Beneficial for the RP-HPLC separation of constitutional and diastereomeric azaspirovesamicol isomers
Keywords: Azaspirovesamicol isomers; Silanol sites; Cation-exchange; Silica column; Retention mechanism; Basic analytes; VAChT
Immunohistochemical evidence for synaptic release of glutamate from orexin terminals in the locus coeruleus
Keywords: GABA; PSD-95; rat; synaptophysin; VGluT; VGAT; Cy2; cyanine; Cy3; indocarbocyanine; Cy5; indodicarbocyanine; Dky; donkey; Glu; glutamate; GP; guinea-pig; Gt; goat; LC; locus coeruleus; LDCVs; large dense core vesicles; Ms; mouse monoclonal; NDS; normal do
3D QSAR study, synthesis, and in vitro evaluation of (+)-5-FBVM as potential PET radioligand for the vesicular acetylcholine transporter (VAChT)
Keywords: Benzovesamicol derivative; VAChT; Triazene; Fluoro-dediazoniation; 3D QSAR