کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1988836 | 1540458 | 2014 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Cellular profile of the dorsal raphe lateral wing sub-region: Relationship to the lateral dorsal tegmental nucleus
ترجمه فارسی عنوان
مشخصات سلولی زیر بخش بالایی ریف پشتی: ارتباط با هسته قاعدهی پشتی جانبی
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
TrpHVAChT5HT1Aserotonin-1A receptorGADLDTNOSDRN5HTcAMP - cAMPglutamic acid decarboxylase - glutamic acid dearboxylaseCyclic adenosine monophosphate - آدنوزین مونوفسفات CyclicACh - آهAcetylcholine - استیل کولینGamma aminobutyric acid - اسید گاما آمینو بوتیریکMidline - خط مقدمDorsal raphé - رفسنجی پشتیSerotonin - سروتونینNitric oxide - نیتریک اکسیدnitric oxide synthase - نیتریک اکسید سنتازdorsal raphe nucleus - هسته رافهlateral dorsal tegmental nucleus - هسته قاعدهی پشتی جانبیtryptophan hydroxylase - هیدروکسیلاز تریپتوفانChAT - چتcholine acetyl transferase - کولین استیل ترانسفرازGABA - گابا
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
چکیده انگلیسی
As one of the main serotonergic (5HT) projections to the forebrain, the dorsal raphe nucleus (DRN) has been implicated in disorders of anxiety and depression. Although the nucleus contains the densest population of 5HT neurons in the brain, at least 50% of cells within this structure are non-serotonergic, including a large population of nitric oxide synthase (NOS) containing neurons. The DRN has a unique topographical efferent organization and can also be divided into sub-regions based on rostro-caudal and medio-lateral dimensions. NOS is co-localized with 5HT in the midline DRN but NOS-positive cells in the lateral wing (LW) of the nucleus do not express 5HT. Interestingly, the NOS LW neuronal population is immediately rostral to and in line with the cholinergic lateral dorsal tegmental nucleus (LDT). We used immunohistochemical methods to investigate the potential serotonergic regulation of NOS LW neurons and also the association of this cell grouping to the LDT. Our results indicate that >75% of NOS LW neurons express the inhibitory 5HT1A receptor and are cholinergic (>90%). The findings suggest this assembly of cells is a rostral extension of the LDT, one that it is subject to regulation by 5HT release. As such the present study suggests a link between 5HT signaling, activation of cholinergic/NOS neurons, and the stress response including the pathophysiology underlying anxiety and depression.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Chemical Neuroanatomy - Volumes 57â58, May 2014, Pages 15-23
Journal: Journal of Chemical Neuroanatomy - Volumes 57â58, May 2014, Pages 15-23
نویسندگان
Rani K. Vasudeva, Barry D. Waterhouse,