کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6810257 | 1433603 | 2011 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Dopamine D1 receptors and age differences in brain activation during working memory
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
سالمندی
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چکیده انگلیسی
In an fMRI study, 20 younger and 20 healthy older adults were scanned while performing a spatial working-memory task under two levels of load. On a separate occasion, the same subjects underwent PET measurements using the radioligand [11C] SCH23390 to determine dopamine D1 receptor binding potential (BP) in caudate nucleus and dorsolateral prefrontal cortex (DLPFC). The fMRI study revealed a significant load modulation of brain activity (higher load > lower load) in frontal and parietal regions for younger, but not older, adults. The PET measurements showed marked age-related reductions of D1 BP in caudate and DLPFC. Statistical control of caudate and DLPFC D1 binding eliminated the age-related reduction in load-dependent BOLD signal in left frontal cortex, and attenuated greatly the reduction in right frontal and left parietal cortex. These findings suggest that age-related alterations in dopaminergic neurotransmission may contribute to underrecruitment of task-relevant brain regions during working-memory performance in old age.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neurobiology of Aging - Volume 32, Issue 10, October 2011, Pages 1849-1856
Journal: Neurobiology of Aging - Volume 32, Issue 10, October 2011, Pages 1849-1856
نویسندگان
Lars Bäckman, Sari Karlsson, HÃ¥kan Fischer, Per Karlsson, Yvonne Brehmer, Anna Rieckmann, Stuart W.S. MacDonald, Lars Farde, Lars Nyberg,