The theoretical analysis of the scale-up possibilities in a DTM crystallizer

• The new theoretical approach to scale-up in DTM crystallizers is presented.
• The drawbacks of the classical approach (dimensional analysis) are discussed.
• The kinetic and fluid dynamics requirements used in the scale-up problem solution.
• The departure from geometrical similarity and constant PCT criterion is proposed.
• Practical verification of the discussed method in the industrial scale.

A scale-up of crystallization process is a very important yet not solved issue. In this paper the theoretical reasoning considering this problem is presented. The classical method involving preservation of geometrical similarity is discussed. The alternative way to success leading through combination of hydraulic and kinetic requirements is presented. This approach involves departure from geometrical similarity together with primary circulation time (PCT) as a scale-up criterion.