Equilibria and kinetics of reactive extraction of pranoprofen enantiomers from organic solution

Equilibria and kinetics for reactive extraction of pranoprofen (PRA) enantiomers with methyl-β-cyclodextrin (Me-β-CD) in water as diluent were reported. The theory of extraction accompanied by a chemical reaction has been used to obtain the kinetics. The reactions between Me-β-CD and PRA enantiomers fall in Regime 3. The reactions are first order with respect to PRA and second order with respect to Me-β-CD. The forward rate constants are 2.82 × 10−4 m6/(mol2 s) for S-PRA and 3.53 × 10−4 m6/(mol2 s) for R-PRA, respectively. The developed extraction model is suitable to analyze and evaluate the reactive extraction of PRA enantiomers by Me-β-CD.

► Kinetics study on reactive extraction of PRA enantiomers with Me-β-CD as chiral selector is reported.
► Extraction rate is mainly controlled by chemical reactions when agitation speed is fast enough.
► The reactions are first order with respect to PRA and second with respect to Me-β-CD.
► The established model can accurately predict the extraction process.