Characterization of ICAM-1 biophore to design cytoadherence blocking peptides

- IB peptide binds to ICAM1 to block cytoadherence of RBCs towards ECs.
- The molecular modeling has identified the biophoric environment of IB peptide.
- IB peptide is optimized to block PfEMP1 binding region site on ICAM1.
- IBT 213 exhibits significant better interaction than template peptide.
- MD analysis indicates the stability of ICAM1:IBT213 model at ambient temperature.
- IBT213 does not block LFA-1 binding site on ICAM1.
- IBT213 has potential to develop blocking peptide to inhibit EC-RBC cytoadherence.