Similarity-based virtual screening for microtubule stabilizers reveals novel antimitotic scaffold

- Similarity screening yields new molecules with tubulin binding affinities.
- One of the new molecules possesses a novel highly rigid scaffold.
- Modifications of the new hits produce great binding enhancements.
- Rescoring the binding energies confirms findings.
- Physicochemical properties of novel ligands are superior to known tubulin binders.