کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6920833 | 864433 | 2016 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
TDSDMI: Inference of time-delayed gene regulatory network using S-system model with delayed mutual information
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
مهندسی کامپیوتر
نرم افزارهای علوم کامپیوتر
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: TDSDMI: Inference of time-delayed gene regulatory network using S-system model with delayed mutual information TDSDMI: Inference of time-delayed gene regulatory network using S-system model with delayed mutual information](/preview/png/6920833.png)
چکیده انگلیسی
Regulatory interactions among target genes and regulatory factors occur instantaneously or with time-delay. In this paper, we propose a novel approach namely TDSDMI based on time-delayed S-system model (TDSS) model and delayed mutual information (DMI) to infer time-delay gene regulatory network (TDGRN). Firstly DMI is proposed to delete redundant regulator factors for each target gene. Secondly restricted gene expression programming (RGEP) is proposed as a new representation of the TDSS model to identify instantaneous and time-delayed interactions. To verify the effectiveness of the proposed method, TDSDMI is applied to both simulated and real biological datasets. Experimental results reveal that TDSDMI performs better than the recent reconstruction methods.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Computers in Biology and Medicine - Volume 72, 1 May 2016, Pages 218-225
Journal: Computers in Biology and Medicine - Volume 72, 1 May 2016, Pages 218-225
نویسندگان
Bin Yang, Wei Zhang, Haifeng Wang, Chuandong Song, Yuehui Chen,