Reliability analysis of a mini-instrument for simultaneous monitoring water content, deep tissue temperature, and hemodynamic parameters

Autoimmune diseases, congenital genetic diseases, cancer and other diseases originated by immune or genetic problems threaten public health. Gene/cell therapy is a highlighted potential method for the treatment of these diseases. But it causes cytokine storm, which probably triggers multiple organ failure, acute respiratory distress syndrome and so on. In this work, a novel device for monitoring multiple physiological parameters response to cytokine storm is designed. Some measures are taken to make custom device have better sensitivity, specificity and robustness, including utilization of twisted-pair line, design of 50 Hz trap filter, and utilization of voltage follower. Several reliability tests of this device are conducted, which includes sensitivity test, stability test and pre-clinical experiments. The results of these reliability tests demonstrate that custom device has good sensitivity, stability and reliability and potential for measuring human physiological parameters.