Rational evaluation of the utilization of PEG-PEI copolymers for the facilitation of silica nanoparticulate systems in biomedical applications

- mPEG-PEI copolymers were prepared, the interaction mechanisms with SiNP were studied.
- Electrostatic attractions govern the adsorption process of mPEGlowPEI copolymer.
- Hydrogen bonding takes part in the adsorption process of mPEGhighPEI copolymer.
- Increased PEG grafting density does not prevent serum protein adsorption.
- Inverse dependence of PEG grafting density was observed under biological conditions.