کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
7043 530 2012 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Biomechanical and angiogenic properties of tissue-engineered rat trachea using genipin cross-linked decellularized tissue
موضوعات مرتبط
مهندسی و علوم پایه مهندسی شیمی بیو مهندسی (مهندسی زیستی)
پیش نمایش صفحه اول مقاله
Biomechanical and angiogenic properties of tissue-engineered rat trachea using genipin cross-linked decellularized tissue
چکیده انگلیسی

In this study, the obtainment and characterization of decellularized rat tracheal grafts are described. The detergent-enzymatic method, already used to develop bioengineered pig and human trachea scaffolds, has been applied to rat tracheae in order to obtain airway grafts suitable to be used to improve our knowledge on the process of tissue-engineered airway transplantation and regeneration. The results demonstrated that, after 9 detergent-enzymatic cycles, almost complete decellularized tracheae, retaining the hierarchical and mechanical properties of the native tissues with strong in vivo angiogenic characteristics, could be obtained. Moreover, to improve the mechanical properties of decellularized tracheae, genipin is here considered as a naturally derived cross-linking agent. The results demonstrated that the treatment increased mechanical properties, in term of secant modulus, without neither altering the pro-angiogenic properties of decellularized airway matrices or eliciting an in vivo inflammatory response.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biomaterials - Volume 33, Issue 3, January 2012, Pages 780–789
نویسندگان
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