کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
7062047 1459427 2018 16 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Beneficial effect of sequential chemotherapy treatments of lung cancer patients revealed by calorimetric monitoring of blood plasma proteome denaturation
ترجمه فارسی عنوان
اثر مثبت درمان های ترکیبی شیمیدرمانی در بیماران مبتلا به سرطان ریه با استفاده از نظارت کالری سنجی دیناراسیون پروتئوم پلاسمای خون
موضوعات مرتبط
مهندسی و علوم پایه مهندسی شیمی جریان سیال و فرایندهای انتقال
چکیده انگلیسی
Blood plasma heat capacity profiles of lung cancer patients were recorded by DSC and monitored during a first-line chemotherapy cycle including four sessions of treatment by a platinum-based doublet of cisplatin or carboplatin in combination with a third-generation agent (paclitaxel, gemcitabine, or docetaxel). The heat capacity profiles were deconvoluted into the major blood proteome constituent peaks, and the thermodynamic parameters of the peaks −temperature, relative area, and relative maximum heat capacity - were determined. The deconvolution procedure allowed identification of characteristic differences from the control profiles of healthy volunteers. As a result of the chemotherapy sessions, the parameters of the thermograms of the patients shifted towards the “healthy” signature profile, thus providing a specific new, DSC-based criterion that allows evaluating the efficacy of the chemotherapy treatment.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Thermochimica Acta - Volume 659, 10 January 2018, Pages 1-7
نویسندگان
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