A comparative uncertainty study of the purity assessment of chemical reference substances using differential scanning calorimetry (DSC) and mass balance method

► We introduce the DSC method for the purity assessment of chemical reference substances (CRSs). ► The uncertainty of high-purity CRSs calibrated by the DSC are similar with the mass balance method. ► Increasing the impurities of CRSs will increase the uncertainty of the DSC.