کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
7139177 | 1462020 | 2018 | 32 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Copper(II)-mediated sliver nanoclusters as a fluorescent platform for highly sensitive detection of alendronate sodium
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آنالیزی یا شیمی تجزیه
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Copper(II)-mediated sliver nanoclusters as a fluorescent platform for highly sensitive detection of alendronate sodium Copper(II)-mediated sliver nanoclusters as a fluorescent platform for highly sensitive detection of alendronate sodium](/preview/png/7139177.png)
چکیده انگلیسی
Alendronate sodium (ALDS) is an important and regularly used medicine in clinical therapy of osteoporosis. In this work, a new analytical method is developed for the detection of ALDS based on a fluorescent platform of copper(II)-mediated silver nanoclusters (AgNCs). Specifically, Cu2+ can selectively bind with DNA-stabilized AgNCs and thus greatly quench their red fluorescence. In the presence of ALDS, their fluorescence can largely recover again owing to the stronger coordination of ALDS with Cu2+. On the basis of such a mechanism, fluorescence “on-off-on” mode of the nanoprobe is applied to detect ALDS in a wide linear range of 800 pM-200â¯Î¼M, with a detection limit of 100â¯pM. Compared with previously reported methods, the present approach has significant advantages regard to simplicity, high sensitivity, and a wide detectable concentration range. This method has been successfully applied in ALDS assay in tablets and human body fluids.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Sensors and Actuators B: Chemical - Volume 269, 15 September 2018, Pages 271-277
Journal: Sensors and Actuators B: Chemical - Volume 269, 15 September 2018, Pages 271-277
نویسندگان
Chunyan Jia, Jingchuan Shang, Yi Wang, Lijuan Bai, Chao Tong, Yongjie Chen, Pu Zhang,