کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
7139244 | 1462019 | 2018 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Microfluidic approach for in situ synthesis of nanoporous silver microstructures as on-chip SERS substrates
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موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آنالیزی یا شیمی تجزیه
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چکیده انگلیسی
Nanoporous silver microstructures (np-AgMSs) were first in situ synthesized using a microfluidic system. Chloride induced precipitation with NH4OH was used to prepare AgCl as a sacrificial template. Exploiting the microfluidic platform, effects of reactant concentrations on the morphology of AgCl templates were studied by simply adjusting the input flow rates. The AgCl templates were subsequently reduced into Ag0 or np-AgMSs using chemical reduction. The synthesized np-AgMSs were tested as on-chip SERS substrates using p-aminothiophenol as an analyte. It was found that the np-AgMSs with multipod structures (tripod and tetrapod) provided the highest SERS signal compared to other structures. Finally, the multipod np-AgMSs were successfully used as on-chip SERS substrates for determination of thiocyanate in human saliva. Linearity of the proposed approach was found to be in the range of 1-20â¯Î¼M with R2â¯=â¯0.9887. The LOD and LOQ were 0.1 and 1.5â¯Î¼M, respectively. Accuracy of the system was investigated from % recovery of spiked thiocyanate standard solutions and found to be in the range of 90-110%. In addition, reproducible Raman signals of thiocyanate were achieved with relative standard deviations of less than 9% for both intraday and interday SERS measurements. These indicated high accuracy and precision of the whole system.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Sensors and Actuators B: Chemical - Volume 270, 1 October 2018, Pages 466-474
Journal: Sensors and Actuators B: Chemical - Volume 270, 1 October 2018, Pages 466-474
نویسندگان
Duangtip Lawanstiend, Harnchana Gatemala, Supeera Nootchanat, Sanong Eakasit, Kanet Wongravee, Monpichar Srisa-Art,