کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
7144754 | 1462065 | 2016 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Womb-on-a-chip biomimetic system for improved embryo culture and development
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آنالیزی یا شیمی تجزیه
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Womb-on-a-chip biomimetic system for improved embryo culture and development Womb-on-a-chip biomimetic system for improved embryo culture and development](/preview/png/7144754.png)
چکیده انگلیسی
The 3D biomimetic microsystem described in this research integrates various functions of the fallopian tube to serve as an in vitro platform for fertilization and embryonic development. This device mimics the in vivo embryo-endometrial stromal cell monolayer coculture to enhance the group culture of embryos and mechanically culture the embryos in a dynamic manner to enhance their development. The microdevice presented here is compared with static culture for embryonic development rate in the presence and absence of epithelial cells. The results suggest that the dynamic biomimetic microsystem enhances the rate of embryo development, providing a culture environment that closely mimics the in vivo microenvironment. This all-in-one biomimetic microsystem has the potential to replace the present embryo culture platforms used for assisting in vitro fertilization.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Sensors and Actuators B: Chemical - Volume 226, April 2016, Pages 218-226
Journal: Sensors and Actuators B: Chemical - Volume 226, April 2016, Pages 218-226
نویسندگان
Kuo-Wei Chang, Pei-Yu Chang, Hong-Yuan Huang, Chin-Jung Li, Chang-Hung Tien, Da-Jeng Yao, Shih-Kang Fan, Wensyang Hsu, Cheng-Hsien Liu,