Highly sensitive amperometric sensor for carbamazepine determination based on electrochemically reduced graphene oxide-single-walled carbon nanotube composite film

We report a highly sensitive amperometric sensor for the determination of carbamazepine (CBZ) at an electrochemically reduced graphene oxide (ERGO) and single walled carbon nanotube (SWCNT) composite film modified glassy carbon electrode (GCE). The π-π stacking interactions between ERGO and SWCNT add good stability to the composite film which was confirmed by UV-visible and FTIR spectroscopy. Compared with SWCNT modified electrode, ERGO-SWCNT composite film modified electrode exhibits a 3.2 fold enhancement in peak current for CBZ oxidation. The proposed sensor detects CBZ as low as 29 nM and has a sensitivity of 5.1076 μA μM−1 cm−2 in the linear range of 50 nM to 3 μM. The practicality of this sensor has been evaluated by the determination of CBZ from Tegratol tablets showing good sensitivity and linearity.