کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
7149811 | 1462120 | 2012 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Determination of metronidazole in pharmaceutical dosage forms based on reduction at graphene and ionic liquid composite film modified electrode
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آنالیزی یا شیمی تجزیه
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Determination of metronidazole in pharmaceutical dosage forms based on reduction at graphene and ionic liquid composite film modified electrode Determination of metronidazole in pharmaceutical dosage forms based on reduction at graphene and ionic liquid composite film modified electrode](/preview/png/7149811.png)
چکیده انگلیسی
An electrochemical method has been successfully demonstrated for sensitive determination of Metronidazole (MTZ) with graphene (Gr)-room temperature ionic liquid (IL) of 1-butyl-3-methylimidazolium hexafluorophosphate (BMIMPF6) composite modified glassy carbon electrode (GCE). The cyclic voltammetric results indicate that Gr-IL/GCE can remarkably enhance electrocatalytic activity towards the reduction of MTZ in neutral solutions. MTZ produce a cathodic peak at about â0.69 V at this electrode. The electrochemical parameters of MTZ in the composite film were carefully calculated with the results of the charge transfer coefficient (α) as 0.625 and the number of electron transferred (n) as 4. The electrocatalytic behavior was further exploited as a sensitive detection scheme for the MTZ determination by differential-pulse voltammetry (DPV). Under optimized conditions, the concentration range and detection limit were 1.0 Ã 10â7-2.5 Ã 10â5 mol Lâ1 and 4.7 Ã 10â8 mol Lâ1 (S/N = 3), respectively for MTZ. The method was successfully applied assay of the drug in the pharmaceutical dosage forms.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Sensors and Actuators B: Chemical - Volume 169, 5 July 2012, Pages 81-87
Journal: Sensors and Actuators B: Chemical - Volume 169, 5 July 2012, Pages 81-87
نویسندگان
Jinyun Peng, Chuantao Hou, Xiaoya Hu,