کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
7150123 | 1462120 | 2012 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Effective surface modification of gold nanorods for localized surface plasmon resonance-based biosensors
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آنالیزی یا شیمی تجزیه
پیش نمایش صفحه اول مقاله
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چکیده انگلیسی
This paper presents a novel, pH-mediated protocol for the surface modification of gold nanorods (GNRs), which provides a robust platform for the assembly of localized surface plasmon resonance (LSPR)-based sensors, by facilitating functionalization at the surface of the nanoparticles. This is achieved by replacing the surface bilayer of cetyltrimethylammonium bromide (CTAB) with 11-mercaptoundecanoic acid (MUA) at alkaline pH after seed-mediated growth of GNRs. This method fully exploits the characteristics of MUA (i) the carboxylic acid functionality enables ligand exchange in an aqueous environment; (ii) the hydrophobic nature of the molecule stabilizes the nanorods and prevents aggregation via a self-assembled monolayer and (iii) the sulfur moiety binds to the gold surface. Critically, this procedure also simplifies subsequent functionalization, overcoming the limitation arising from commonly used CTAB-only preparation. XPS (X-ray photoelectron spectroscopy) was used to confirm the ligand exchange at the surface of the GNRs. The surface modification facilitates the preparation of a LSPR-based biosensor based on human IgG for the detection of anti-human IgG and a detection limit of 0.4Â nM was observed.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Sensors and Actuators B: Chemical - Volume 169, 5 July 2012, Pages 360-367
Journal: Sensors and Actuators B: Chemical - Volume 169, 5 July 2012, Pages 360-367
نویسندگان
Jie Cao, Ewan K. Galbraith, Tong Sun, Kenneth T.V. Grattan,