کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
7206913 | 1469059 | 2018 | 20 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Design of a remote-control drug delivery implantable chip for cancer local on demand therapy using ionic polymer metal composite actuator
ترجمه فارسی عنوان
طراحی یک تراشه قابل تعویض داروهای کنترل از راه دور برای سرطان موضعی در صورت تقاضا درمانی با استفاده از دستگاه کامپوزیت پلیمر فلز یونی
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کلمات کلیدی
تحویل مواد مخدر، کامپوزیت فلزی یونی پلیمر، فعال کننده، مخزن مواد مخدر، کنترل از راه دور، زیست سازگاری،
موضوعات مرتبط
مهندسی و علوم پایه
سایر رشته های مهندسی
مهندسی پزشکی
چکیده انگلیسی
Since the local, on demand, cancer therapy is a challenging clinical issue today, this paper presents the design, fabrication and characterization of a remotely controlled single reservoir drug delivery chip using Ionic Polymer Metal Composite (IPMC) actuator. Here, Drug release was externally programmed and controlled wirelessly on demand by a communication circuit. The transmitter and receiver circuits were designed to control the release/sealed status remotely even from 7â¯cm distance while the transmitter and receiver were coupled magnetically. IPMC here was used as the moving cap of the reservoir, that in release mode, lets the drug out on demand with a low received power of 20â¯mW. The novel simple design could release the whole content of the drug which is remarkable in comparison with the designs which need complicated optimizations of diffuser, nuzzle and IPMC diaphragm pump, leading to an incomplete release. To make sure that there is no leakage in the sealed mode, IPMC was attached to a polydimethylsiloxane (PDMS) support film. Biocompatibility of all the components of the chip were tested by 3-(4,5-dimethylthiazol-2-yl)ââ¯2,5-diphenyltetrazolium bromide (MTT) assay.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of the Mechanical Behavior of Biomedical Materials - Volume 86, October 2018, Pages 250-256
Journal: Journal of the Mechanical Behavior of Biomedical Materials - Volume 86, October 2018, Pages 250-256
نویسندگان
Matin Sadat Saneei Mousavi, Amir Hossein Karami, Mehrshad Ghasemnejad, Mohammadreza Kolahdouz, Faranak Manteghi, Farangis Ataei,