کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
7207125 | 1469064 | 2018 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Reinforced chitosan membranes by microspheres for guided bone regeneration
ترجمه فارسی عنوان
غشاء های کیتوزان تقویت شده توسط میکروسپرس برای بازسازی هدایت شده استخوان
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کلمات کلیدی
بازسازی هدایت استخوان، کیتوزان، نانو هیدروکسی آپاتیت / کیتوزان میکروسپارس، تقویت سیتو سازگاری،
موضوعات مرتبط
مهندسی و علوم پایه
سایر رشته های مهندسی
مهندسی پزشکی
چکیده انگلیسی
In order to improve the osteogenic activity and mechanical strength of the guided bone regeneration (GBR) membrane for repairing bone defect, nano-hydroxyapatite/chitosan (nHA/CS) composite microspheres were prepared through in situ biomimetic method, then composite microspheres were incorporated into CS membrane. The morphologies and mechanical properties of the composite membranes were investigated through scanning electronic microscopy (SEM) and universal mechanical testing machine. The results show that the in situ biomimetic nHA/CS microspheres were embedded in CS membrane and were integrated tightly with CS matrix. The mechanical properties of GBR membranes containing in situ nHA/CS microspheres is significantly higher than that of membranes containing pure CS microspheres and blending nHA/CS microspheres. Its elongation rate at break reaches 5.61â¯Â±â¯0.95%. The elastic modulus and strength of the GBR membranes can reach 766.27â¯Â±â¯20.68 and 43.32â¯Â±â¯0.95â¯MPa, respectively. Further, The work-of-fracture of the membranes with in situ microspheres approaches 2.71â¯Â±â¯0.25â¯J/m2, which is about 3 times of the pure CS membrane. The cell culture results display that the GBR membranes containing in situ biomimetic nHA/CS microspheres exhibit good cytocompatibility.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of the Mechanical Behavior of Biomedical Materials - Volume 81, May 2018, Pages 195-201
Journal: Journal of the Mechanical Behavior of Biomedical Materials - Volume 81, May 2018, Pages 195-201
نویسندگان
Di Huang, Lulu Niu, Jian Li, Jingjing Du, Yan Wei, Yinchun Hu, Xiaojie Lian, Weiyi Chen, Kaiqun Wang,