کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
7208250 | 1469091 | 2016 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Shear-mediated crystallization from amorphous calcium phosphate to bone apatite
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
سایر رشته های مهندسی
مهندسی پزشکی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
The contribution of fluid shear stress (FSS) on the conversion of amorphous calcium phosphate (ACP) to bone apatite is investigated. The ACP precursors are prepared by using a wet-chemistry method and further exposed to the constant FSS environment with values of 0.5, 1.0, 1.5, and 2.0 Pa. At the designated time points, the apatites are characterized by transmission electron microscopy, X-ray diffraction, and inductively coupled plasma-mass spectroscopy. The results show that, the low FSS (â¤1.0 Pa) has positive effects on the transition of ACP, characterized by the accelerated crystallization velocity and the well-organized calcium-deficient hydroxyapatite (CDHA) structure, whereas the high FSS (>1.0 Pa) has negative effects on this conversion process, characterized by the poor CDHA crystal morphologies and the destroyed structures. The bioactivity evaluations further reveal that, compared with the FSS-free group, the CDHA prepared under 1.0 Pa FSS for 9 h presents the more biocompatible features with pre-osteoblast cells. These results are helpful for understanding the mechanism of apatite deposition in natural bone tissue.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of the Mechanical Behavior of Biomedical Materials - Volume 54, February 2016, Pages 131-140
Journal: Journal of the Mechanical Behavior of Biomedical Materials - Volume 54, February 2016, Pages 131-140
نویسندگان
Xufeng Niu, Liyang Wang, Feng Tian, Lizhen Wang, Ping Li, Qingling Feng, Yubo Fan,