Synthesis, spectroscopy characterization and biological activities of some novel 1-(3-(N,N-dimethylamino)-1-(5-substituted thiophene-2-yl) propylidene semicarbazone Mannich base derivatives

The main aim of this work was to synthesise a novel 1-(3-(N,N-dimethylamino)-1-(5-substituted thiophene-2-yl)propylidene semicarbazone Mannich base derivatives and examine the anti-diabetic and anti-inflammatory activities using alloxan-induced diabetic and carrageenan-induced paw oedema methods. These analogues were prepared by performing a condensation reaction between 1-(thiophen 2-yl) ethanone, formaldehyde, N,N-dimethyl amine hydrochloride and semicarbazide. The prepared analogues were characterised by FT-IR, 1H NMR, 13C NMR, mass spectroscopy and elemental analysis. The result reveals that most of the compounds were significantly reduced in the blood glucose level and inflammation of paw volume of experimental animals as compared to the standard drugs.