Structural control and hemostatic properties of porous microspheres fabricated by hydroxyapatite-graft-poly(D,L-lactide) nanocomposites

Nanocomposite microspheres with tunable porous structures were studied in this work as hemostatic agents. Hydroxyapatite nanoparticles-graft-poly(D,L-lactide) (nHA-g-PDLLA) nanocomposites were synthesized first and then fabricated into porous microspheres by a modified double emulsion solvent evaporation technique. Alkaline treatment were carried out on nanocomposite microspheres for the exposure of HA nanoparticles on the surface of porous microspheres. The porous structure and nanocomposition endue the nHA-g-PDLLA microspheres with huge specific surface area and excellent interfaces for blood clotting. This work reveals the great potentials of nHA-g-PDLLA nanocomposite microspheres as hemostatic agents.