کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
7215212 | 1469502 | 2016 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Synergistic reinforcement of polydopamine-coated hydroxyapatite and BMP2 biomimetic peptide on the bioactivity of PMMA-based cement
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
سایر رشته های مهندسی
مهندسی (عمومی)
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
To be better used as implant materials in bone regeneration, bioactivity and osteogenesis of poly(methyl methacrylate) (PMMA)-based bone cement need to be further enhanced. In this study, bioactive hydroxyapatite (HA) nanoparticle decorated with polydopamine (pDA) and BMP2 mimicking peptide (serine-serine-valine-proline-threonine, SSVPT) was incorporated into PMMA-based cement (px-HA/PMMA). The presence of pDA layer on HA surface could keep the mechanical property of px-HA/PMMA cements comply with the requirement of clinical application. More importantly, the px-HA/PMMA cement exhibited excellent biomechanical property with enhanced interfacial adhesion between cement and swine femur. Biomineralization and cell experiment in vitro showed that the incorporation of pDA-coated HA and SSVPT can synergistically enhance the bioactivity of px-HA/PMMA cement for regeneration and provide an attractive strategy to reconstruction of load-bearing bone.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Composites Science and Technology - Volume 123, 8 February 2016, Pages 232-240
Journal: Composites Science and Technology - Volume 123, 8 February 2016, Pages 232-240
نویسندگان
Ting Kang, Xiaoli Hua, Peiqing Liang, Minyu Rao, Qin Wang, Changyun Quan, Chao Zhang, Qing Jiang,