A PK-PD MODEL OF CELL CYCLE RESPONSE TO TOPOTECAN

A model describing the response of the growth of single human cells in the absence and presence of the anti-cancer agent, topotecan, is presented. The model is a result of linking the pharmacokinetic (pK) and pharmacodynamic (pD) responses. By linking the models in this way, rather than using separate (static) approaches, it is possible to illustrate how the drug perturbs the cell cycle. The model is validated for a range of drug concentrations with experimental data.