کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
7235687 1471087 2018 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Biomechanical analysis of fluid percussion model of brain injury
ترجمه فارسی عنوان
تجزیه و تحلیل بیومکانیک مدل سکته مغزی آسیب مغزی
کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه سایر رشته های مهندسی مهندسی پزشکی
چکیده انگلیسی
Fluid percussion injury (FPI) is a widely used experimental model for studying traumatic brain injury (TBI). However, little is known about how the brain mechanically responds to fluid impacts and how the mechanical pressures/strains of the brain correlate to subsequent brain damage for rodents during FPI. Hence, we developed a numerical approach to simulate FPI experiments on rats and characterize rat brain pressure/strain responses at a high resolution. A previous rat brain model was improved with a new hexahedral elements-based skull model and a new cerebrospinal fluid (CSF) layer. We validated the numerical model against experimentally measured pressures from FPI. Our results indicated that brain tissues under FPI experienced high pressures, which were slightly lower (10-20%) than input saline pressure. Interestingly, FPI was a mixed focus- and diffuse-type injury model with highest strains (12%) being concentrated in the ipsilateral cortex under the fluid-impact site and diffuse strains (5-10%) being spread to the entire brain, which was different from controlled cortical impact in which high strains decreased gradually away from the impact site.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Biomechanics - Volume 77, 22 August 2018, Pages 228-232
نویسندگان
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