کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
7236019 | 1471090 | 2018 | 25 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Effect of severe bioprosthetic valve tissue ingrowth and inflow calcification on valve-in-valve performance
ترجمه فارسی عنوان
تأثیر افزایش تولید بافت دریچه جداسازی و جریان کلسفیکاسیون بر عملکرد شیر در شیر
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
سایر رشته های مهندسی
مهندسی پزشکی
چکیده انگلیسی
While in vivo studies clearly demonstrate that supra-annular Valve-in-Valve (ViV) implantation provides the highest probability for optimal post-ViV pressure gradients (PG), there is still no physical insight into explaining anomalies where some supra-annular ViV implantations yield high pressure gradients while some sub-annular implantations yield low pressure gradients. The aim of this study is to explain how severe tissue ingrowth and calcification (TIC) in a surgical aortic valve (SAV) can be one physical mechanism leading to anomalous ViV performance characteristic. The ViV hemodynamic performance was evaluated as a function of axial positioning â9.8, â6.2, 0, and +6â¯mm in SAVs with and without TIC. Effective orifice area (EOA) and PG were compared. Leaflet high-speed imaging and particle image velocimetry were performed to elucidate flutter and forward jet characteristics. ViV without TIC showed significantly lower PG and greater EOA (pâ¯<â¯0.01). EOA and PG improve with supra-annular deployment (pâ¯<â¯0.01) while for ViV with TIC, EOA and PG worsen as the deployment varies from â9.8â¯mm to 0â¯mm (pâ¯<â¯0.01) only to recover atâ¯+â¯6â¯mm (pâ¯<â¯0.01). Separated jet flow at the TIC site, and consequently induced stronger TAV leaflet fluttering highlight the dynamic compromising nature of TIC on jet width and performance reduction. We conclude that the inflow TIC greatly influence ViV performance due to dynamic effects that results in a real anomalous performance characteristic different than that seen in most ViV in vivo. Further in vivo studies are needed to evaluate ViV outcomes in the presence of severe TIC in SAVs.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Biomechanics - Volume 74, 6 June 2018, Pages 171-179
Journal: Journal of Biomechanics - Volume 74, 6 June 2018, Pages 171-179
نویسندگان
Hoda Hatoum, Jennifer Dollery, Scott M. Lilly, Juan A. Crestanello, Lakshmi Prasad Dasi,