CONTROL AND SYNCHRONIZATION OF INTRACELLULAR CALCIUM DYNAMICS: A ROBUST SLIDING CONTROL APPROACH

Intracellular calcium Ca2+ is a ubiquitous second messenger used to activate various cellular processes, including muscle contraction, fertilization and development of deuterostome eggs, cell growth, neuromodulation, synaptic plasticity and sensory perception. In this work we propose a feedback control scheme for both control and synchronization of intracelullar calcium dynamics. The control scheme is based on a high-order robust sliding control approach. Numerical simulations shows the effectivity of the feedback control laws to synchronize two calcium oscillators and for regulation and tracking of a single calicum oscillator.